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| Feature | Exotoxin | Endotoxin (LPS) | |---------|----------|-----------------| | Source | Gram+/Gram- bacteria | Gram-negative only | | Chemistry | Protein | Lipid A + polysaccharide | | Heat stability | Labile (except some) | Stable | | Toxicity | Very high (μg) | Low (mg) | | Effect | Specific (e.g., neurotoxin) | Fever, shock, DIC | | Example | Tetanospasmin, Cholera toxin | E. coli septic shock | coli septic shock | Finding legal, free, and

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