Create a System_Restore_Point before running any new tweak suite. That way, if you accidentally disable your printer spooler, you're two clicks from safety.
Some specific registry tweaks you might find interesting: windows 10 registry tweaks github best
: A portable utility that allows you to toggle common registry-based performance and privacy fixes through a simple interface. Key Performance & Privacy Registry Tweaks Create a System_Restore_Point before running any new tweak